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J Pineal Res (2011) 50(3):267–71

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Concurrently, advanced target deconvolution techniques like thermal proteome profiling (TPP) allow global analysis of thermal stability shifts across 7,000+ proteins (Savitski et al., 2014), as demonstrated by the discovery that CDC42 inhibitors stabilize β-catenin/E-cadherin complexes to suppress renal fibrosis—a mechanism with cross-organ relevance for IPF (Hu et al., 2024)